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Preparation of Microcrystalline Cellulose by Deep Eutectic Solvent Combined with Ball Milling Process and Its Application in Tablets
Received:October 24, 2022  
DOI：10.11980/j.issn.0254-508X.2023.05.014
Key Words:deep eutectic solvents  microcrystalline cellulose  tablets  disintegration performance
Fund Project:广东省植物资源生物炼制重点实验室项目（2021GDKLPRB-K02）；山东省济宁市重点研发计划项目（2022JBZP003）。
Author NameAffiliationPostcode
CHEN Tong* State Key Lab of Pulp and Papermaking Engineering， South China University of Technology， Guangzhou， Guangdong Province， 510640 510640
LI Jun State Key Lab of Pulp and Papermaking Engineering， South China University of Technology， Guangzhou， Guangdong Province， 510640 510640
XU Jun State Key Lab of Pulp and Papermaking Engineering， South China University of Technology， Guangzhou， Guangdong Province， 510640
Guangdong Province Key Lab of Plant Fiber Refinery， Guangzhou， Guangdong Province， 510006 		510006
ZHANG Zhaohui State Key Lab of Pulp and Papermaking Engineering， South China University of Technology， Guangzhou， Guangdong Province， 510640 510640
YING Guangdong Shandong Sunpaper Industry Joint Stock Co.， Ltd.， Jining， Shandong Province， 272100 272100
ZHANG Wei Shandong Sunpaper Industry Joint Stock Co.， Ltd.， Jining， Shandong Province， 272100 272100
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Abstract:Three deep eutectic solvents （DES） of choline chloride/formic acid （ChCl/FA）， choline chloride/oxalic acid （ChCl/OA）， and choline chloride/citric acid （ChCl/CA） were used to treat poplar wood dissolving pulp， combined with ball milling process to prepare microcrystalline cellulose （MCC）. The effects of time and temperature on the properties of MCC polymerization and particle size under different DES systems were investigated. Using ibuprofen as a model drug， MCC was filled as a pharmaceutical excipient to investigate the effects of particle size and dosage of MCC on the properties of tablets such as disintegration time and dissolution degree. The results showed that the MCC prepared by ChCl/FA system at 100 ℃ for 60 min had the best mobility. Without adding disintegrant， when the filling amount of MCC was 35%， the disintegration time and the dissolution degree of tablets within 60 min could reach 190 s and 86.58%， respectively， with high hardness and tensile strength. It showed that MCC prepared via DES method had a better filling effect as a pharmaceutical excipient.
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