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| Lateral Flow Immunoassay Method Based on Surface Enhanced Raman Spectroscopy for Rapid Detection of Heavy Metal Elements in Cigarette Paper |
| Received:September 12, 2024 |
| DOI：10.11980/j.issn.0254-508X.2025.01.012 |
| Key Words:cigarette paper heavy metal rapid detection SERS lateral flow immunoassay |
| Fund Project:烟草行业标准项目（2021B023）；国家烟草专卖局重大科技项目（110202101080（SJ-04））。 |
| Author Name | Affiliation | Postcode | | DONG Hao | China National Tobacco Quality Supervision and Test Center, Zhengzhou, He’nan Province, 450001
Hefei Institutes of Physical Science of CAS, Hefei, Anhui Province, 230031 | 230031 | | HU Xingfeng | China Tobacco Chongqing Industrial Co., Ltd., Chongqing, 400060 | 400060 | | BAI Wenlong | Hefei Institutes of Physical Science of CAS, Hefei, Anhui Province, 230031 | 230031 | | ZHENG Shuai | Hefei Institutes of Physical Science of CAS, Hefei, Anhui Province, 230031 | 230031 | | HUANG Zhi | China Tobacco Chongqing Industrial Co., Ltd., Chongqing, 400060 | 400060 | | LIU Hua* | China Tobacco Chongqing Industrial Co., Ltd., Chongqing, 400060 | 400060 | | WANG Shu | Hefei Institutes of Physical Science of CAS, Hefei, Anhui Province, 230031 | 230031 | | ZHOU Mingzhu | China National Tobacco Quality Supervision and Test Center, Zhengzhou, He’nan Province, 450001 | 450001 | | XING Jun | China National Tobacco Quality Supervision and Test Center, Zhengzhou, He’nan Province, 450001 | 450001 |
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| Abstract:To achieve highly sensitive， quantifiable， and rapid detection of heavy metals in cigarette paper， a novel lateral flow immunoassay technique based on surface enhanced raman spectroscopy （SERS） signals was studied and proposed. SERS lateral flow immunoassay method utilized a raspberry-like SERS label Fe3O4@Raspberry-like Au magnetic nanoparticles （Fe@RAu） to capture metal residues in samples. Au shell on the Fe@RAu surface could generate Raman hot spot effects to enhance the Raman signals of DTNB molecules modified on its surface， while its Fe3O4 core could be attracted by external magnetic forces to concentrate targets in the sample. Based on these characteristics， SERS lateral flow immunoassay method demonstrated ultra-high detection sensitivity and quantification capability. The results showed that the SERS lateral flow immunoassay method achieved sensitivity levels of 1.424， 0.937， and 1.568 ng/kg for the simultaneous detection of three heavy metals， including cadmium （Cd2+）， chromium （Cr3+）， and lead （Pb2+） in cigarette paper ash. The spiked recovery rate for actual cigarette paper standard samples was>90%， the relative standard deviation （RSD）was<10%， and the entire detection process （including pretreatment） was<30 min. |
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