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| Preparation of Hemicelluloses-based pH Sensitive Hydrogel and Its Application in Controlled Drug Release |
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| DOI：10.11980/j.issn.0254-508X.2019.04.004 |
| Key Words:water insoluble hemicelluloses polyvinyl alcohol pH sensitive hydrogels drug controlled release |
| Fund Project:广州市科技计划项目（201607020025）。 |
| Author Name | Affiliation | | XU Mengjie | State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangzhou, Guangdong Province, 510640 | | LI Weibing | State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangzhou, Guangdong Province, 510640 | | ZHOU Xuesong* | State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangzhou, Guangdong Province, 510640 |
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| Abstract:A kind of novel pH-sensitive hemicelluloses-based hydrogels was synthesized from the water insoluble hemicelluloses (wis-AGX)（the composition of neutral monosaccharide was 83.09% xylose, 10.03% glucose, 4.76% arabinose and 0.76% galactose）extracted from corncobs via sequential graft copolymerization, saponification hydrolysis in alkaline medium, blending with polyvinyl alcohol（PVA）and crosslinkage in presence of glutaraldehyde.The chemical structure of the composite hydrogel was characterized by NMR and Fourier transform infrared spectroscopy, and the morphological characteristics of the hydrogel were characterized by scanning electron microscopy. The swelling properties of the hydrogels in distilled water and buffer solutions with different pH values were studied, respectively. The results show that the hydrogel has obvious pH sensitivity, and the swelling rate is the highest at pH=10, up to 1210%. In addition, the swelling rate of the hydrogel is positively correlated with the content of —COOH and negatively correlated with the amount of glutaraldehyde. Using theophylline as a model drug, its drug release behavior in simulated gastric fluid (pH=1.2) and intestinal fluid (pH=7.4) was investigated. Within 6 h, the cumulative release of the drug-loaded gel in the simulated intestinal fluid was up to 68%, which was significantly higher than the cumulative release of 51% of the drug in the gastric juice, so hydrogel has obvious drug sustained release effect and pH sensitivity. |
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