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| Determination of Aromatic Amines in Cigarette Paper by Using Liquid Chromatography Tandem Mass Spectrometry |
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| DOI：10.11980/j.issn.11-1967/TS.2015.04.009 |
| Key Words:cigarette paper aromatic amines liquid chromatography-tandem mass spectrometry |
| Fund Project:福建中烟工业有限责任公司资助项目“烟用材料高度关注物芳香胺等5类检测方法的研究与建立”(FJZYJH2014012)。 |
| Author Name | Affiliation | | ZHANG Ting-gui | Technology Center of China Tobacco Fujian Industrial Corporation, Xiamen, Fujian Province, 361022 | | DENG Qi-xin | Technology Center of China Tobacco Fujian Industrial Corporation, Xiamen, Fujian Province, 361022 | | LIN Yan | Technology Center of China Tobacco Fujian Industrial Corporation, Xiamen, Fujian Province, 361022 | | LIU Ze-chun | Technology Center of China Tobacco Fujian Industrial Corporation, Xiamen, Fujian Province, 361022 | | XU Han-chun | Technology Center of China Tobacco Fujian Industrial Corporation, Xiamen, Fujian Province, 361022 | | XIE Wei* | Technology Center of China Tobacco Fujian Industrial Corporation, Xiamen, Fujian Province, 361022 |
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| Abstract:In this paper, a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for measuring 20 kinds of aromatic amines in cigarette paper was established. The sample was first extracted by citrate buffer and the aromatic amines were reduced by adding sodium dithionite, the extract was then concentrated on a solid phase extraction column and eluted by methanol. The elution was condensed and solved for LC-MS/MS analysis. The recoveries of the method were in the range of 77.5%～112.1%, while the relative standard deviation (RSD) change from 1.4%～13.4%, the limit of detection was lower than 0.1 ng/mL. The developed method was of good efficiency, sensitivity and selectivity, and could been successfully applied to determine the aromatic amines in cigarette paper． |
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