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Cellulose Nanocrystals as Carriers for Hydrophobic Naringenin to Enhance Its Anti-oxidation Activity
Received:July 03, 2019  
DOI：10.11980/j.issn.0254-508X.2019.09.002
Key Words:cellulose nanocrystals  naringenin  nanolization  dissolution  anti-oxidation
Fund Project:湖南省林业科技计划项目 20131028湖南省林业科技计划项目（20131028）。
Author NameAffiliationPostcode
LIU Yanxin School of Materials and Engineering, Central South University of Forestry and Technology, Changsha, Hu'nan Province, 410004
School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hu'nan Province, 410114 		410114
LI Xiangzhou School of Materials and Engineering, Central South University of Forestry and Technology, Changsha, Hu'nan Province, 410004
ational Engineering Lab for Applied Technology of Forestry &
Ecology in South, Changsha, Hu'nan Province, 410004) （* ） 		410004
ZHOU Jun School of Materials and Engineering, Central South University of Forestry and Technology, Changsha, Hu'nan Province, 410004 410004
LIU Qingjian School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hu'nan Province, 410114 410114
HAN Junyuan School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hu'nan Province, 410114 410114
WANG Yue School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hu'nan Province, 410114 410114
WANG Yulong School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hu'nan Province, 410114 410114
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Abstract:As a typical flavonoid, naringenin exhibits attractive pharmacological activities, including anti-inflammatory, anti-oxidation, anti-cancer properties, and lowering lipids. However, due to its poor water solubility and low bioavailability in aqueous solutions, the pharmaceutical application of naringenin is very limited. In this study, cellulose nanocrystals (CNCs) were used as carriers for naringenin, and the CNCs/naringenin nanocomposite was prepared based on anti-solvent recrystallization method. The CNCs/naringenin nanocomposite was characterized and its dissolution and anti-oxidation activity in aqueous systems were investigated. The results showed that naringenin was effectively nanolized and well dispersed, as well as transformed from crystalline state to amorphous state in aqueous system based on the formation of CNCs/naringenin nanocomposite. The cumulative dissolution of naringenin in CNCs/naringenin nanocomposite obviously increased to 93.4% at 120 min. Furthermore, the in vitro anti-oxidation activity of naringenin was clearly enhanced based on the formation of CNCs/naringenin nanocomposite. The above results supported the conclusion that the use of CNCs as nanocarriers for naringenin was a promising technique to improve the bioavailability of naringenin in aqueous systems.
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